Selective COX-2 inhibitor reduces bone healing in bone defects
نویسندگان
چکیده
منابع مشابه
Selective COX-2 inhibitor reduces bone healing in bone defects.
Anti-inflammatory agents have been reported to regulate bone healing. The aim of this study was to investigate the effect of a selective cyclooxygenase-2 inhibitor (meloxicam) on bone healing in calvarial defects in rats. Thirty-six adult male Wistar rats were included. After anesthesia, a linear incision was made through the skin of the scalp, a full-thickness flap was reflected and a 4 mm rou...
متن کاملHealing Large Bone Defects
Large bone defects and non-union fractures, especially in the diaphysis, represent a challenging and complex interaction of mechanical and biological factors. Fortunately, many of these problem fractures can be successfully managed by stabilization and autologous cancellous bone grafting. However, in some patients autologous cancellous bone graft collection can be associated with morbidity, or ...
متن کاملHealing Large Bone Defects
Large bone defects and non-union fractures, especially in the diaphysis, represent a challenging and complex interaction of mechanical and biological factors. Fortunately, many of these problem fractures can be successfully managed by stabilization and autologous cancellous bone grafting. However, in some patients autologous cancellous bone graft collection can be associated with morbidity, or ...
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Whether non-steroidal anti-inflammatory drug (NSAID)-induced suppression of bone ingrowth is due to cyclooxygenase-1 (COX-1) inhibition, cyclooxygenase-2 (COX-2) inhibition, or through a yet unidentified pathway is unknown. In this study, the effects of a non-specific COX-1 and COX-2 inhibitor, versus a specific COX-2 inhibitor on bone ingrowth and tissue differentiation are examined in vivo. H...
متن کاملSelective COX-2 Inhibitor (Meloxicam) and Tooth-Supporting Bone Quality. A Histomorphometric Study in Rats.
The effects of the non-steroidal anti-inflammatory drugs (NSAIDs) on bone quantity and quality were investigated for years. However, there is lack of information on the impact of NSAIDs on the quality of tooth-supporting alveolar bone in absence of periodontal inflammation. Thus, the aim of this study was to evaluate histometrically the influence of a selective COX-2 NSAID (Meloxicam) on the in...
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ژورنال
عنوان ژورنال: Brazilian Oral Research
سال: 2005
ISSN: 1806-8324
DOI: 10.1590/s1806-83242005000400014